March 7, 2018. Silenseed announced the publication of a new scientific paper named “Ammonium and arsenic trioxide are potent facilitators of oligonucleotide function when delivered by gymnosis”, by Xiaowei Zhang, Daniela Castanotto, Xueli Liu, Amotz Shemi and Cy A. Stein, in Nucleic Acids Research, 2018, 1. In this work, authors have identified ammoniumion (NH4+) as a non-toxic potent enhancer of oligonucleotide (ON) activity in the nucleus and cytoplasm. Enhancement of function can be found in attached and suspension cells, including in difficult-to-transfect Jurkat T and CEM T cells.